HCID 590919, Verbindung → Ethyl 3-(2-fluorophenyl)propanoate

HRID 362828

Reaktionsgleichung

Reaktionsgleichung von HRID 362828
[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H]>C(O)C.O.[Pt]=O>[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

Komponenten

5

Edukt 2

HCID 590919HCID 590919, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 14879014Ethyl 3-(2-fluorophenyl)propanoateAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 86587499Platinum oxide monohydrateKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 2-fluorocinnamate (29.25 g, 0.176 mol) and platinum oxide hydrate (0.25, EM Scientific) in 95% ethanol (150 mL) was placed on a Parr hydrogenation apparatus and shaken under 2-4 atm at hydrogen pressure. After the appropriate amount of hydrogen was consumed, the catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give 29.39 g (99%) of crude ethyl 3-(2-fluorophenyl)propionate. This material was used without further purification.

Aufarbeitung

  1. customAfter the appropriate amount of hydrogen was consumed
  2. customthe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-804027412b4e4b3593bfa9c776543599
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05872118

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