4-(3-Fluorophenyl)-3-buten-1-ol → 3-Fluoro-benzenebutanol

HRID 363081Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 363081
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH2:10][CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1.[H][H]>[C].[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 536388864-(3-Fluorophenyl)-3-buten-1-olHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 540408183-Fluoro-benzenebutanolAusbeute 89,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

In a reaction vessel were placed 0.53 g of 4-(3-fluorophenyl)-3-buten-1-ol and 50 ml of ethyl acetate, and the air in the vessel was exchanged for nitrogen. Then, 0.1 g of 10% palladium carbon was added thereto, and the nitrogen in the vessel was exchanged for hydrogen, followed by vigorous stirring at room temperature for 24 hours. After the hydrogen in the vessel was exchanged for nitrogen, the reaction solution was filtered through a celite bed, and the filtrate was concentrated. The residue was subjected to silica gel chromatography, which afforded 0.48 g of 4-(3-fluorophenyl)-1-butanol.

Aufarbeitung

  1. customIn a reaction vessel were placed
  2. filtrationthe reaction solution was filtered through a celite bed
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-329321572bed4df2bf1df618f2db5072
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05872137

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