Sodium amide → 2-Amino-3-Phenyl-6-methylpyridine

HRID 363199

Reaktionsgleichung

Reaktionsgleichung von HRID 363199
[C:1]1([C:7]2[CH:8]=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2-:14].[Na+]>CCN(C1C=CC=CC=1)CC>[NH2:14][C:8]1[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=[C:10]([CH3:13])[N:9]=1

Komponenten

4

Edukt 2

HCID 24533Sodium amideHCID 767442-Methyl-5-phenylpyridine

Produkt 1

HCID 463146392-Amino-3-Phenyl-6-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7061N,N-DiethylanilineLösungsmittel

Versuchsvorschrift

A solution of 3-phenyl-6-methyl pyridine (0.815 g, 4.82 mmol), and sodium amide (752 mg, 19.3 mmol) in diethylaniline (10 mL) was heated at 180° C. for 72 hours. The reaction was cooled and quenched with ice (100 g), and the mixture extracted with EtOAc. The organic extract was washed with brine (50 mL), dried (MgSO4), silica gel (100 g) was added and the solvent evaporated in vacuo.

Aufarbeitung

  1. temperatureThe reaction was cooled
  2. customquenched with ice (100 g)
  3. extractionthe mixture extracted with EtOAc
  4. extractionThe organic extract
  5. washwas washed with brine (50 mL)
  6. dry with materialdried (MgSO4), silica gel (100 g)
  7. additionwas added
  8. customthe solvent evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-32a3396c1d2b456c8dbc096b5c0cb0df
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05872136

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