Phosphorus tribromide → 3-Methoxybenzyl bromide

HRID 36341

Reaktionsgleichung

Reaktionsgleichung von HRID 36341
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]O.P(Br)(Br)[Br:12]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][Br:12]

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 814373-Methoxybenzyl alcohol

Produkt 1

HCID 40672073-Methoxybenzyl bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.

Aufarbeitung

  1. extractionThe reaction mixture is extracted with ether
  2. washthe organic layer washed with saturated sodium bicarbonate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d0021b55fed847d8be332381521d5721
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05414001

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