Ethyl Acetate → Benzenebutanal, 4-(phenylmethoxy)-

HRID 363802

Reaktionsgleichung

Reaktionsgleichung von HRID 363802
S([O-])([O-])(=O)=O.[Mg+2].[CH:7]1[C:12]([C@@H:13](O)[CH2:14]N)=[CH:11][C:10]([OH:17])=[C:9](O)[CH:8]=1.[C:19]([O:22][CH2:23][CH3:24])(=O)[CH3:20]>[Pt]>[CH2:23]([O:22][C:19]1[CH:20]=[CH:11][C:12]([CH2:7][CH2:8][CH2:9][CH:10]=[O:17])=[CH:13][CH:14]=1)[C:24]1[CH:11]=[CH:12][CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 3

HCID 8857Ethyl Acetate3×HCID 24083Sulfuric acid magnesium salt (1:1)HCID 439260Norepinephrine

Produkt 1

HCID 11086308Benzenebutanal, 4-(phenylmethoxy)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23939PlatinumKatalysator

Versuchsvorschrift

A solution of 4-(4-benzyloxyphenyl)-butanal (52.4 g, 206 mmol) in 150 mL ethyl acetate (1.4M solution) was prepared and set aside. 10% platinum on carbon (3.40 g) was prewetted with ethyl acetate and transferred to the reactor. To this was added magnesium sulfate (60.0 g, 500 mmol), followed by the ethyl acetate solution of (trimethylsilyl)-protected norepinephrine prepared as described in Example 1.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-becb9cf850d841398405eae6e1336a80
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05874601

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