Hydrochloric Acid → 2-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid

HRID 364175Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 364175
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[O:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:9]=1[C:10]([O:12]C)=[O:11].[OH-].[K+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[O:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:9]=1[C:10]([OH:12])=[O:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 136890962-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid, methyl ester

Produkt 1

HCID 136890952-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirred suspension of 65 g of 2-(5-chloro-2-nitrophenoxy)-5-methoxybenzoic acid, methyl ester, in 600 ml of methanol, was added 97.5 ml of 6M KOH solution. This suspension was stirred for 18 hours and the solution which resulted was neutralized with 200 ml of 10% HCl solution. The precipitated crude acid product was collected by filtration and, after recrystallization from acetonitrile, yielded the title compound, mp 232°-234° C.

Aufarbeitung

  1. customthe solution which resulted
  2. customThe precipitated crude acid product
  3. filtrationwas collected by filtration
  4. customafter recrystallization from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-274139536c184ed5bdb934812ae3ee22
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604390

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