Ammonia → HCID 178512201, Verbindung

HRID 364327

Reaktionsgleichung

Reaktionsgleichung von HRID 364327
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:12][CH2:13][C:14]([F:17])([F:16])[F:15])=S)[CH:6]=[CH:7][CH:8]=1.[NH3:18]>>[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[NH:18])[CH:6]=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 212987211-(3-Hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)thiourea

Produkt 1

HCID 178512201HCID 178512201, Verbindung

Versuchsvorschrift

The above thiourea (1.32 g.) was stirred in 1.6N alcoholic ammonia (50 ml.) with mercuric oxide (3.4 g.) for 17 hours at 20°. The resulting mixture was clarified on the centrifuge and the supernatant was evaporated in vacuo to a syrup which was further dried at 70°/0.1 m.m. to give 1-(3-hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)guanidine. The n.m.r. spectrum in d6 dimethylsulphoxide using tetramethyl silane as internal standard (δ=0) had the following resonances (δ): 6.9 (4H, multiplet); 4.4 (2H, singlet); 3.9 (2H, quartet).

Aufarbeitung

  1. customthe supernatant was evaporated in vacuo to a syrup which
  2. customwas further dried at 70°/0.1 m

Quellen und Nachweise

ORD-Eintrag
ord-cf3463c8daf344ce91c87e99fc4a683d
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604465

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