1-Methoxy-2-propanol → 2-Hydroxycyclohexyloxymethoxypropane

HRID 36477

Reaktionsgleichung

Reaktionsgleichung von HRID 36477
[CH3:1][O:2][CH2:3][CH:4]([OH:6])[CH3:5].[CH:7]12[O:13][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]2>[OH-].[Na+]>[OH:6][CH:4]([CH3:5])[CH2:3][O:2][CH2:1][O:13][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:7]1

Komponenten

4

Edukt 2

HCID 79001-Methoxy-2-propanol2×HCID 9246Cyclohexene oxide

Produkt 1

HCID 677825022-HydroxycyclohexyloxymethoxypropaneAusbeute 27,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideKatalysator

Versuchsvorschrift

45 g (0.5 mole) of propylene glycol methyl ether (PM), 33 g (0.33 mole) of cyclohexene oxide and 0.3 g (0.007 mole) of sodium hydroxide were charged in a 100 ml eggplant type flask equipped with a reflux tube, and a reaction was allowed to proceed under reflux at a temperature for a reflux reaction for 10 hours. Results of the analysis of the resultant reaction mixture by GC showed that the conversion of PM was 20%. Then, the obtained reaction mixture was subjected to distillation, to thereby obtain 17 g of 2-hydroxycyclohexyloxymethoxypropane, i.e., propylene glycol methyl 2-hydroxycyclohexyl ether (hereinafter referred to as "PGMHCHE"). The IR spectrum of the product is shown in FIG. 3. Other properties of the product were measured and results are shown in Table 1.

Aufarbeitung

  1. customequipped with a reflux tube
  2. temperatureunder reflux at a temperature for a reflux reaction for 10 hours
  3. customResults of the analysis of the resultant
  4. customreaction mixture by GC
  5. customThen, the obtained reaction mixture
  6. distillationwas subjected to distillation

Quellen und Nachweise

ORD-Eintrag
ord-7d7484beac2744609639badf1d0f58b5
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05414144

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