2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 1-Piperazinecarboxamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-cyclopentyl-

HRID 364885

Reaktionsgleichung

Reaktionsgleichung von HRID 364885
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH:22]1([N:27]=[C:28]=[O:29])[CH2:26][CH2:25][CH2:24][CH2:23]1>O1CCOCC1>[CH:22]1([NH:27][C:28]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:16]=[C:15]([NH2:17])[C:14]4[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=4)[N:8]=3)[CH2:2][CH2:3]2)=[O:29])[CH2:26][CH2:25][CH2:24][CH2:23]1

Komponenten

4

Edukt 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 643500Cyclopentyl Isocyanate

Produkt 1

HCID 1572951-Piperazinecarboxamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-cyclopentyl-Ausbeute 83,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

In 30 ml of dioxane, there was dissolved 1.16 g. (4 mmole) of 2-piperazino-4-amino-6,7-dimethoxyquinazoline. To the resultant solution was added dropwise 0.45 g. (4 mmole) of cyclopentyl isocyanate at room temperature and the mixture was stirred overnight at room temperature. The precipitated crystals were recovered by filtration to obtain 1.34 g. of the desired product.

Aufarbeitung

  1. filtrationThe precipitated crystals were recovered by filtration
  2. customto obtain 1.34 g

Quellen und Nachweise

ORD-Eintrag
ord-9dffeeef4c7a473db638aaa2bc8bade2
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04607034

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