Chlorosulfonic acid → 3-Methoxy-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride

HRID 364895

Reaktionsgleichung

Reaktionsgleichung von HRID 364895
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:12]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1

Komponenten

4

Edukt 2

HCID 24638Chlorosulfonic acidHCID 744146-Methoxytetralin

Produkt 1

HCID 132103423-Methoxy-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

118 g (0.73 mole) of 5,6,7,8-tetrahydro-2-naphthol methyl ether are dissolved in 320 ml of methylene chloride, and 177 ml of chlorosulfonic acid in 160 ml of methylene chloride are added. The mixture is stirred for 10 minutes at 5° C. and is poured into ice water. The organic phase is separated off and dried with MgSO4. The solvent is removed by evaporation and the residue is recrystallized from acetone/petroleum ether.

Aufarbeitung

  1. customThe organic phase is separated off
  2. dry with materialdried with MgSO4
  3. customThe solvent is removed by evaporation
  4. customthe residue is recrystallized from acetone/petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-9bacb43ee4cb43199d5ffc4dd58e4573
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04607030

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