Chlorosulfonic acid → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

HRID 364909

Reaktionsgleichung

Reaktionsgleichung von HRID 364909
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[CH:9][C:8]=1[OH:16])=[O:4].[Cl:17][S:18](O)(=[O:20])=[O:19]>>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:18]([Cl:17])(=[O:20])=[O:19])[C:8]=1[OH:16])=[O:4]

Komponenten

3

Edukt 2

HCID 24638Chlorosulfonic acidHCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

Produkt 1

HCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

Versuchsvorschrift

70 g (0.29 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxyindane are dissolved in 150 ml of chlorosulfonic acid, and the mixture is stirred for approx. 30 minutes at room temperature. The mixture is poured into ice water and the product is filtered off with suction. The initially crystalline material becomes oily after a little time and is employed in the next stage in this form without further purification.

Aufarbeitung

  1. filtrationthe product is filtered off with suction
  2. customis employed in the next stage in this form without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b261b528b5324d1898ca17168a21389b
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04607030

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