HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 11-[1-(2,4,6-Trimethylbenzyl)piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 2,4,6-Trimethylbenzyl chloride | HCID 74108 | — |
| Edukt | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 11-[1-(2,4,6-Trimethylbenzyl)piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689365 | — |
Reaktionsschritte
To 60 ml DMF, was added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.0 g, 0.0186 mole), 2,4,6-trimethylbenzyl chloride (4.2 g, 0.025 mole), milled K2CO3 (15 g, 0.1 mole) and KI (0.01 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04608374 |
| Quelldatensatz | uspto-grants-1986_08 |
| ORD ID | ord-95986a814d71420e9dc0d340917a98b5 |
| Quellennotiz | uspto-grants-1986_08 |