Thionyl Chloride → 1-(4-Cyanobenzyl)-5-(chloromethyl)imidazole

HRID 365463Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 365463
[C:1]([C:3]1[CH:16]=[CH:15][C:6]([CH2:7][N:8]2[C:12]([CH2:13]O)=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].S(Cl)([Cl:19])=O>>[C:1]([C:3]1[CH:16]=[CH:15][C:6]([CH2:7][N:8]2[C:12]([CH2:13][Cl:19])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 101982471-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole

Produkt 1

HCID 97953581-(4-Cyanobenzyl)-5-(chloromethyl)imidazole

Versuchsvorschrift

A solution of 1-(4-cyanobenzyl)-5-(hydroxymethyl)-imidazole (1.0 g, 4.70 mmol), in thionyl chloride (5 ml), was stirred at 70° C. for 16 hrs. The solvent was evaporated in vacuo and the resulting solid suspended in CH2C12, collected by filtration and dried in vacuo. The material was sufficiently pure to be used without further purification.

Aufarbeitung

  1. customThe solvent was evaporated in vacuo
  2. filtrationcollected by filtration
  3. customdried in vacuo
  4. customto be used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-43d6ba044f5c4b9281759f776b5bc10f
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06127366

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