HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Methyl 4-cyanobenzoate | HCID 70791 | — |
| Edukt | Ethyl 2-Amino-5-methylthiophene-3-carboxylate | HCID 4062885 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate | HCID 23289523 | 119,2% |
Reaktionsschritte
5 g of 2-amino-5-methyl-3-ethoxycarbonyl-thiophene is dissolved with 2.7 g of methyl 4-cyanobenzoate in 40 ml of dioxane. Gaseous HCl is then passed through the solution for 5 hours. After customary working up, 6 g of methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate are obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06130223 |
| Quelldatensatz | uspto-grants-2000_10 |
| ORD ID | ord-b5561ede14be4856aff16dad24a13583 |
| Quellennotiz | uspto-grants-2000_10 |