4-Fluoroaniline → HCID 70255947, Verbindung
Reaktionsgleichung
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.O=[C:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[C:15]#[N:16].[Cl-].[Ca+2].[Cl-]>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:10]2[CH2:14][CH2:13][CH2:12][C:11]=2[C:15]#[N:16])=[CH:4][CH:3]=1Komponenten
4
Versuchsvorschrift
4-Fluoro-aniline (Aldrich Chemicals) (2.3 g, 21 mmol), cyano-ketone (Example 11) (2.2 g, 20 mmol), calcium chloride (2.5 g, 23 mmol) and T.H.F. (30 ml) were heated under reflux for 21 hours. After being allowed to cool, the mixture was filtered and the solvent evaporated. Kugelrohr distillation (160° C., 0.4 mm Hg) gave the product as an off-white powder.
Aufarbeitung
- temperature(30 ml) were heated
- temperatureunder reflux for 21 hours
- temperatureto cool
- filtrationthe mixture was filtered
- customthe solvent evaporated
- distillationKugelrohr distillation (160° C., 0.4 mm Hg)
Quellen und Nachweise
- ORD-Eintrag
- ord-b79fefa60f7d47428fa503d0599f1070
- Quelldatensatz
- uspto-grants-2000_10
- Patentnummer
- US06130228
Notizen zur Reaktion
Wird geladen…