1-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperazine → HCID 23289234, Verbindung

HRID 366429

Reaktionsgleichung

Reaktionsgleichung von HRID 366429
[CH3:1][C:2]1[S:3][C:4]2[C:10]([O:11][CH:12]3[CH2:18][CH2:17][CH2:16][CH:15]4[CH:13]3[O:14]4)=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH:19]1[C:29]2[CH2:28][CH2:27][C:26]3[CH:30]=[CH:31][CH:32]=[CH:33][C:25]=3[CH:24]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)[C:23]=2[CH:22]=[CH:21][CH:20]=1.O1CCOCC1.C1(C)C=CC=CC=1.BrC1CC2C(C2)OC1>C1COCC1>[CH:30]1[C:26]2[CH2:27][CH2:28][C:29]3[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=3[CH:24]([N:34]3[CH2:35][CH2:36][N:37]([CH:15]4[CH2:16][CH2:17][CH2:18][CH:12]([O:11][C:10]5[C:4]6[S:3][C:2]([CH3:1])=[N:6][C:5]=6[CH:7]=[CH:8][CH:9]=5)[CH:13]4[OH:14])[CH2:38][CH2:39]3)[C:25]=2[CH:33]=[CH:32][CH:31]=1.[CH3:1][C:2]1[S:3][C:4]2[C:10]([O:11][CH:12]3[CH2:18][CH2:17][CH2:16][CH:15]4[CH:13]3[O:14]4)=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1

Komponenten

7

Edukt 4

HCID 27359361-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperazineHCID 21840791Dioxane tolueneHCID 232892932-Methyl-7-(7-oxa-bicyclo[4.1.0]hept-2-yloxy)-benzothiazoleHCID 232893314-Bromo-2-oxa-bicyclo[4.1.0]heptane

Produkt 2

HCID 23289234HCID 23289234, VerbindungHCID 232892932-Methyl-7-(7-oxa-bicyclo[4.1.0]hept-2-yloxy)-benzothiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The title compound was prepared according to Method A from 2-methyl-7-(7-oxa-bicyclo[4.1.0]hept-2-yloxy)-benzothiazole and 1-(10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)piperazine with dioxane/toluene (2:1) as the solvent. mp 207° C. (decomposition); LSIMS m/z 540. The 2-methyl-7-(7-oxa-bicyclo[4.1.0]hept-2-yloxy)-benzothiazole was prepared according to Method IV using THF as the solvent and 4-bromo-2-oxa-bicyclo[4.1.0]heptane as the alkylating agent.

Quellen und Nachweise

ORD-Eintrag
ord-67ee121c137b4d01a6ddf9c39fb83777
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06130217

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