5-Methoxyindole-2-carboxylic acid → 1-(chloromethyl)-3-[(5-methoxyindol-2-yl)carbonyl]-5-nitro-1,2-dihydro-3H-benz[e]indole

Beteiligte Stoffe

Reaktionsschritte

Deprotection of 13 (260 mg, 0.72 mmol) as in Example C, and reaction with 5-methoxyindole-2-carboxylic acid (145 mg, 0.76 mmol) and EDCI.HCl (344 mg, 1.80 mmol) in DMA (3 mL) gave 14d (237 mg, 76%), mp (2×EtOAc/iPr2O) 241-243° C. 1H NMR [(CD3)2SO] δ 11.73 (d, J=1.3 Hz, 1 H, NH), 9.16 (s, 1 H, H-4), 8.35 (dd, J=7.2, 2.5 Hz, 1 H, H-6), 8.23 (dd, J=6.9, 2.4 Hz, 1 H, H-9), 7.79-7.70 (m, 2 H, H-7,8), 7.42 (d, J=8.9 Hz, 1 H, H-7'), 7.20 (d, J=1.9 Hz, 1 H, H-3'), 7.17 (d, J=2.4 Hz, 1 H, H-4'), 6.94 (dd, J=9.0, 2.4 Hz, 1 H, H-6'), 4.93 (dd, J=10.6, 9.2 Hz, 1 H, H-2), 4.70 (dd, J=10.9, 2.4 Hz, 1 H, H-2), 4.65-4.57 (m, 1 H, H-1), 4.18-4.07 (m, 2 H, CH2Cl), 3.79 (s, 3 H, OCH3).

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