HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonium thiocyanate → 2-[N-(4-bromophenyl)-N-ethylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonium thiocyanate | HCID 15666 | — |
| Edukt | Thionyl Chloride | HCID 24386 | — |
| Edukt | 2-Chloronicotinic acid | HCID 76258 | — |
| Edukt | 4-bromo-N-ethylaniline | HCID 11745656 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-[N-(4-bromophenyl)-N-ethylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one | HCID 23287574 | 75,3% |
Reaktionsschritte
The reaction procedure of Example 57 was followed except that 1.203 g (7.63 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 639 mg of ammonium thiocyanate, 15 ml of acetone, 1.53 g of N-ethyl-4-bromoaniline and 10 ml of acetone were used. The product was then recrystallized from ethanol to obtain 2.08 g of 2-[N-(4-bromophenyl)-N-ethylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06133258 |
| Quelldatensatz | uspto-grants-2000_10 |
| ORD ID | ord-fa28f574ce1144d4a70656d542ed6a6a |
| Quellennotiz | uspto-grants-2000_10 |