4-Chloro-4'-nitrobenzophenone → 4-Amino-4'-chlorobenzophenone

HRID 36719

Reaktionsgleichung

Reaktionsgleichung von HRID 36719
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1>C(O)C.[Pt]=O>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]([C:5]2[CH:17]=[CH:18][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:7])=[CH:9][CH:10]=1

Komponenten

4

Edukt 1

HCID 3477714-Chloro-4'-nitrobenzophenone

Produkt 1

HCID 35287064-Amino-4'-chlorobenzophenoneAusbeute 79,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 14.4g (54.8 mmol) of 4-chloro-4'-nitrobenzophenone and 66.9 mg, (0.5 mole %) of platinum oxide was stirred under hydrogen in 300 ml of ethanol for 2 hours The mixture was filtered, evaporated and purified by flash column chromatography (2-8% EtOAc/CH2C12) to obtain 10.05 g (72%) of the desired product as a yellow solid. 1H nmr (CDCl3) δ4.16 (2H, br s), 6.67 (2H, d), 7.43 (2H, d), 7.68 (2H, d), 7.69 (2H, d).

Aufarbeitung

  1. filtrationwas filtered
  2. customevaporated
  3. custompurified by flash column chromatography (2-8% EtOAc/CH2C12)

Quellen und Nachweise

ORD-Eintrag
ord-53781cf8028d4ddc9316d7676db2b9e0
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05416112

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