HCID 19937697, Verbindung → 2-Phenyl-1-tetralone

HRID 36740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 36740
[CH2:1]([Mg]Br)[CH3:2].Cl[CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1(C1C=CC=CC=1)[OH:16]>C1C=CC=CC=1>[C:2]1([CH:6]2[CH2:15][CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]2=[O:16])[CH:1]=[CH:8][CH:7]=[CH:6][CH:15]=1

Komponenten

4

Edukt 2

HCID 19937697HCID 19937697, VerbindungHCID 178418443HCID 178418443, Verbindung

Produkt 1

HCID 3483282-Phenyl-1-tetraloneAusbeute 187,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Step C Add ethylmagnesium bromide (1.76 mL, 5.27 mmol, M in) dropwise to a 0° C. solution of 2-chloro-1-phenyl-1,2,3,4-tetrahydronaphth-1-ol (1.36 g, 5.27 mmol) in dry benzene (20 mL). Stir the solution at 0° C. for 30 min and heat to reflux for 5 hours. Cool the mixture to room temperature and quench with saturated NH4Cl (aqueous). Extract with ether, combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to provide 1.1 g (94%) of the title compound.

Aufarbeitung

  1. temperatureheat
  2. temperatureto reflux for 5 hours
  3. temperatureCool the mixture to room temperature
  4. customquench with saturated NH4Cl (aqueous)
  5. extractionExtract with ether
  6. washwash with water and brine
  7. dry with materialdry over Na2SO4
  8. concentrationconcentrate

Quellen und Nachweise

ORD-Eintrag
ord-a1ff33aa23844205b97f4101a245f871
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05416118

Notizen zur Reaktion

Wird geladen…