Ethyl 2-fluoro-5-nitrocarbanilate → Ethyl 5-amino-2-fluorocarbanilate

HRID 36798Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 36798
[F:1][C:2]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][C:3]=1[NH:4][C:5](=[O:9])[O:6][CH2:7][CH3:8].[H][H]>[C].[Pd].C(O)C>[NH2:14][C:11]1[CH:12]=[CH:13][C:2]([F:1])=[C:3]([CH:10]=1)[NH:4][C:5](=[O:9])[O:6][CH2:7][CH3:8]

Komponenten

5

Edukt 2

HCID 2754990Ethyl 2-fluoro-5-nitrocarbanilateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 19937926Ethyl 5-amino-2-fluorocarbanilateAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

100.3 mg (10 wt %) of 5% palladium carbon (containing water) was added to a mixture of 1.00 g (4.39 mmol) of ethyl 2-fluoro-5-nitrocarbanilate and 20 ml of ethanol, and the resultant mixture was stirred until 309 ml of hydrogen was absorbed. The reaction mixture was filtered to remove the catalyst, and the solvent was then distilled off under a reduced pressure. Thus, 700 mg of the objective product (yield: 81%) was obtained in the form of light brown crystals.

Aufarbeitung

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. customto remove the catalyst
  4. distillationthe solvent was then distilled off under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b0f5a2a0fb2a496cacb3d62cd4530814
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05416236

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