Sodium Hydroxide → 2-Chloro-1,3-thiazole-4-carboxylic acid

HRID 368686Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 368686
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([Cl:13])[S:11][CH:12]=1)=[O:7])C>C(O)C>[Cl:13][C:10]1[S:11][CH:12]=[C:8]([C:6]([OH:7])=[O:5])[N:9]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

Produkt 1

HCID 218030262-Chloro-1,3-thiazole-4-carboxylic acidAusbeute 61,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of NaOH (1.9 g, 47.5 mmol) and ethyl-2-chloro-4-thiazolecarboxylate (7.6 g, 40 mmol) in 100 mL absolute ethanol was stirred at RT for 4 h. After that, ethanol was removed in vacuo and the residue was dissolved in water. The aq layer was washed with ether and then acidified with conc HCl. The solid was filtered and air dried to give 4 g of 2-chloro-4-thiazolecarboxylic acid.

Aufarbeitung

  1. customAfter that, ethanol was removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. washThe aq layer was washed with ether
  4. filtrationThe solid was filtered
  5. customair dried

Quellen und Nachweise

ORD-Eintrag
ord-f59266bf3c414010b3d766565c3ded01
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133252

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