Dichloromethane methanol → 1-[2-(Isochroman-1-yl)ethyl]-4-(3-methoxyphenyl)piperazine dihydrochloride
Reaktionsgleichung
[OH2:1].[ClH:2].Cl.[CH:4]1([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=C[CH:25]=[CH:24][C:23]=3OC)[CH2:18][CH2:17]2)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]O1.[CH3:30][OH:31].[Cl:32][CH2:33]Cl>>[ClH:32].[ClH:2].[CH:4]1([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:23]=[CH:24][CH:25]=[C:30]([O:31][CH3:33])[CH:27]=3)[CH2:18][CH2:17]2)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6][O:1]1Komponenten
3
Versuchsvorschrift
Following the general procedure of EXAMPLE 1 and making non-critical variations but using 1-(3-methoxyphenyl)piperazine dihydrochloride (XI, 0.5173 g, 1.95 mmol) in place of 1-(2-chlorophenyl)piperazine dihydrochloride (XI), the title compound is obtained (chromatography using methanol/dichloromethane, 1/99), mp 189.5-193°; MS (m/z) 352; IR (mineral oil) 2373, 1460, 1512, 1048, 748 and 1291 cm-1.
Quellen und Nachweise
- ORD-Eintrag