6-Chloro-1-(2-chloroethyl)isochroman → 1-[2-(6-Chloroisochroman-1-yl)ethyl]-4-(4-methoxyphenyl)piperazine dihydrochloride
Reaktionsgleichung
[Cl:1]C1C=C2C(=CC=1)C(CCCl)[O:7][CH2:6]C2.[OH2:15].[ClH:16].Cl.[CH:18]1([CH2:28][CH2:29][N:30]2[CH2:35][CH2:34][N:33]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=3OC)[CH2:32][CH2:31]2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]O1>>[ClH:1].[ClH:16].[Cl:16][C:24]1[CH:23]=[C:22]2[C:27](=[CH:26][CH:25]=1)[CH:18]([CH2:28][CH2:29][N:30]1[CH2:31][CH2:32][N:33]([C:36]3[CH:41]=[CH:40][C:39]([O:7][CH3:6])=[CH:38][CH:37]=3)[CH2:34][CH2:35]1)[O:15][CH2:20][CH2:21]2Komponenten
3
Versuchsvorschrift
Following the general procedure of EXAMPLE 1 and making non-critical variations but using 6-chloro-1-(2-chloroethyl)isochroman (LXIV, 0.2315 g, 0.972 mmol) and 1-(4-methoxyphenyl)piperazine dihydrochloride (XI, 0.3772 g, 1.00 mmol), the title compound is obtained, mp 203.5-208°; MS (m/z) 386; IR (mineral oil) 1512, 2388, 1485, 1261, 1118 and 1105 cm-1.