Ethyl formate → 1-Formyl-4-(4-methoxyphenyl)piperazine

HRID 368826

Reaktionsgleichung

Reaktionsgleichung von HRID 368826
[OH2:1].Cl.Cl.C1(C[CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3OC)[CH2:18][CH2:17]2)C2C(=CC=CC=2)CCO1.[CH:30](OCC)=[O:31]>>[CH:15]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[CH:23]=[CH:24][C:25]([O:31][CH3:30])=[CH:26][CH:27]=2)[CH2:20][CH2:21]1)=[O:1]

Komponenten

3

Edukt 2

HCID 8025Ethyl formateHCID 232889511-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate

Produkt 1

HCID 232887711-Formyl-4-(4-methoxyphenyl)piperazine

Versuchsvorschrift

A mixture of 1-(4-methoxyphenyl)piperazine (XI, 7.41 g) and ethyl formate (108 ml) is stirred at reflux for 3 hr. The mixture is then cooled, concentrated, and the residue chromatographed on silica gel eluting with methanol/dichloromethane (2/98). The appropriate fractions are pooled and concentrated to give 1-formyl-4-(4-methoxyphenyl)piperazine (VI), NMR (CDCl3) δ 3.05, 3.54, 3.71, 3.78, 6.88, 8.10.

Aufarbeitung

  1. temperatureat reflux for 3 hr
  2. temperatureThe mixture is then cooled
  3. concentrationconcentrated
  4. customthe residue chromatographed on silica gel eluting with methanol/dichloromethane (2/98)
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-bf36939d21b241d38a0977748842d6d1
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133446

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