HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(6-Bromoisochroman-1-yl)acetic acid → 1-(3,4-Dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)ethyl]piperazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (6-Bromoisochroman-1-yl)acetic acid | HCID 10540012 | — |
| Edukt | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| Edukt | 1-(3,4-Dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)]acetyl piperazine | HCID 54184920 | — |
| Produkt | 1-(3,4-Dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)ethyl]piperazine | HCID 15487835 | — |
Reaktionsschritte
(6-Bromoisochroman-1-yl)acetic acid (EXAMPLE 22, LXVIII) is coupled with 3,4-dichlorophenylpiperazine (XI) and the resulting amide, 1-(3,4-dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)]acetyl piperazine (LXIII, 1.66 mmol) is reduced following the general procedure of EXAMPLE 50 and making non-critical variations, to give the title compound, HRMS Calcd for C21H23N2O1Br1Cl2 =468.0371, found=418.0363.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06133446 |
| Quelldatensatz | uspto-grants-2000_10 |
| ORD ID | ord-0f98be8bb4ac480198b31f22d9a190ac |
| Quellennotiz | uspto-grants-2000_10 |