4-(Piperazin-1-yl)benzene-1-sulfonamide → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzenesulfonamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-(Piperazin-1-yl)benzene-1-sulfonamide	HCID 901897	—
Edukt	(-)-2-(Isochroman-1-yl)ethanol	HCID 14141298	—
Edukt	4-(Homopiperazin-1-yl)benzenesulfonamide	HCID 17792895	—
Edukt	1-(2-Chloroethyl)-4-methyl-isochroman	HCID 23288938	—
Edukt	(4S)-4-(phenylmethyl)-3-(2-phenylpropionyl)-2-oxazolidinone	HCID 56980759	—
Produkt	(S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzenesulfonamide	HCID 53677310	—

Reaktionsschritte

Following the general procedure for EXAMPLE 48 and making non-critical variations (-)-2-(isochroman-1-yl)ethanol (LXXIX) and 4-(homopiperazin-1-yl)benzenesulfonamide (IV; prepared from 4-fluorobenzenesulfonamide (III) and homopiperazine (II, Aldrich) by the method of EXAMPLE 47 Step 1) give the title compound, MS (m/z) 415; [α]D -50° (c 0.9996, methylene chloride); IR (mineral oil) 1153, 1595, 1102, 1511 and 1316 cm-1.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06133446
Quelldatensatz	uspto-grants-2000_10
ORD ID	ord-d0641541927a4557861986c670484f48
Quellennotiz	uspto-grants-2000_10