HCID 18462171, Verbindung → HCID 15434652, Verbindung

HRID 369485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 369485
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([O-])=O>CO>[NH2:1][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Komponenten

3

Edukt 1

HCID 18462171HCID 18462171, Verbindung

Produkt 1

HCID 15434652HCID 15434652, VerbindungAusbeute 97,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 4-nitro-3-octoxybenzoate (8.7 g, 0.028 mol) was dissolved in 150 mL methanol to form a solution. It was stirred at room temperature in the presence of 10% Pd--C under H2 atmosphere for 29 hours. The reaction mixture was filtered through celite, concentrated to give the product methyl 4-amino-3-octoxybenzoate as an off-white solid (7.6 g, 96%). 1H NMR (300 MHz, CDCl3): 7.25 (d, J=2.1 Hz, 1H), MS calcd (C16H25NO3): 279.2; found: 279.0.

Aufarbeitung

  1. customto form a solution
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-8ffda926189c4560beb6156b0188ecfc
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06137003

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