Benzoyl chloride → 4-Benzyloxy-3-ethyl-5-methylphenyl benzoate

To a mixture of 6.3 g of 4-benzyloxy-3-ethyl-5-methylphenol, 3.2 g of triethylamine and 50 ml of chloroform was added dropwise 4.0 g of benzoyl chloride with stirring at 0° C. After stirring at room temperature for 6 hours, the reaction mixture was concentrated under reduced pressure. To the residue was added 100 ml of 10% hydrochloric acid, which was extracted with 100 ml of ethyl acetate. The ethyl acetate layer was washed with 10% hydrochloric acid, aqueous sodium hydrogencarbonate solution and then saturated sodium chloride solution, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure, which afforded 8.4 g of crude 4-benzyloxy-3-ethyl-5-methylphenyl benzoate (yield, 93%).

1. stirringAfter stirring at room temperature for 6 hours
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionTo the residue was added 100 ml of 10% hydrochloric acid, which
4. extractionwas extracted with 100 ml of ethyl acetate
5. washThe ethyl acetate layer was washed with 10% hydrochloric acid, aqueous sodium hydrogencarbonate solution
6. dry with materialsaturated sodium chloride solution, dried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure, which

ORD-Eintrag

ord-3bd233dbe9904109b7a81ed38e5f9117

Quelldatensatz

uspto-grants-2000_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06140274