2-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine → Pyrrolidin-1-yl(pyrrolidin-2-yl)methanone

HRID 369883Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 369883
[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2CC2C=CC=CC=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[C].[Pd]>[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1

Komponenten

4

Edukt 1

HCID 232826462-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine

Produkt 1

HCID 550904Pyrrolidin-1-yl(pyrrolidin-2-yl)methanoneAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (300 ml) is suspended 5% palladium-carbon (3 g), and thereto is added 2-(1-pyrrolidinyl)carbonyl-1-benzylpyrrolidine (30 g), and the mixture is subjected to catalytic hydrogenation at room temperature under atmospheric pressure. The mixture is filtered, and the filtrate is concentrated under reduced pressure to remove the solvent to give 2-(1-pyrrolidinyl)carbonylpyrrolidine (about 18 g) as an oily product.

Aufarbeitung

  1. customis subjected to catalytic hydrogenation at room temperature under atmospheric pressure
  2. filtrationThe mixture is filtered
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. customto remove the solvent

Quellen und Nachweise

ORD-Eintrag
ord-3fc5a98fccb24020a84daa4a512926d3
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06140330

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