Sodium Hydroxide → 5-Benzofuranacetic acid

HRID 37036Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 37036
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]([O:13]C)=[O:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[OH-].[Na+]>CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]([OH:13])=[O:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 19748760Methyl 2-(benzofuran-5-YL)acetate

Produkt 1

HCID 234388925-Benzofuranacetic acidAusbeute 99,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl benzofuran-5-ylacetate (1.2 gm, 6.3 mmol) was dissolved in methanol (10 mL) and 2N sodium hydroxide (6.5 mL) was added under nitrogen and the mixture was stirred at rt for 3 hr. It was then diluted-with water and extracted with ether. The aqueous layer was acidified with 2N hydrochloric acid and again extracted twice with ethyl acetate. The organic layers were washed with brine, combined, dried over sodium sulfate and evaporated to give 1.1 gm of title compound suitable for the next step.

Aufarbeitung

  1. extractiondiluted-with water and extracted with ether
  2. extractionagain extracted twice with ethyl acetate
  3. washThe organic layers were washed with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e1f85173cb4b40e7912ff01baf9a6454
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05420010

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