Tetrahydrofuran → N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine

HRID 370375Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 370375
CN(O)[C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[Cl:20])[CH:6]=[CH:5][C:4]=1[N+:21]([O-:23])=[O:22].C([N:27]([CH2:30]C)CC)C.Cl[CH2:33][O:34][C:35](=[O:37])[CH3:36].C1C[O:41]CC1>>[CH3:30][NH:27][O:41][CH2:33][O:34][C:35](=[O:37])[CH2:36][C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[Cl:20])[CH:6]=[CH:5][C:4]=1[N+:21]([O-:23])=[O:22]

Komponenten

5

Edukt 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 69366Chloromethyl acetateHCID 20275650HCID 20275650, Verbindung

Produkt 1

HCID 86740180N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine

Versuchsvorschrift

To a solution of N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]hydroxyamine (700 mg, 1.93 mmol) in THF (10 ml) containing triethylamine (1.2 eq.) is added chloromethylacetate (2 eq.). The mixture is stirred at RT overnight. Excess THF is removed and the product is evaporated to dryness and purified to give N-methyl-N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]acetoxymethoxyamine.

Aufarbeitung

  1. customExcess THF is removed
  2. customthe product is evaporated to dryness
  3. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-06264be53c1c4997ae34a1e86f5bd9a6
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04526608

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