Ammonia → 1,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione

HRID 370433

Reaktionsgleichung

Reaktionsgleichung von HRID 370433
Cl.Cl.[OH:3][C:4]1[C:17]2[C:16](=[O:18])[C:15]3[C:10](=[C:11]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH:32]([OH:34])[CH3:33])[CH:12]=[CH:13][C:14]=3[NH:19][CH2:20][CH2:21][NH:22][CH2:23][CH:24]([OH:26])[CH3:25])[C:9](=[O:35])[C:8]=2[C:7]([OH:36])=[CH:6][CH:5]=1.N>CO>[OH:36][C:7]1[C:8]2[C:9](=[O:35])[C:10]3[C:15](=[C:14]([NH:19][CH2:20][CH2:21][NH:22][CH2:23][CH:24]([OH:26])[CH3:25])[CH:13]=[CH:12][C:11]=3[NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH:32]([OH:34])[CH3:33])[C:16](=[O:18])[C:17]=2[C:4]([OH:3])=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 12519551HCID 12519551, Verbindung

Produkt 1

HCID 4330601,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 6.0 g of 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxypropyl)amino]ethyl]amino]anthraquinone dihydrochloride (prepared as described in Example 32 of U.S. Pat. No. 4,197,249) and 60 ml of methanol is treated with ammonia gas according to the procedure of Example 1 to give the corresponding free base, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxypropyl)amino]ethyl]amino]-anthraquinone.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-03c00a3bf826425f870764c02ede44c5
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04526788

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