HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Hydroxide → N-(4,5-Dihydro-1H-imidazol-2-yl)-2-methyl-2H-indazol-4-amine monohydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | 2-Chloro-4,5-dihydroimidazole | HCID 236236 | — |
| Edukt | 2-Chloroimidazoline sulfate | HCID 12503398 | — |
| Edukt | 2-Methyl-2H-indazol-4-amine | HCID 15413170 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | N-(4,5-Dihydro-1H-imidazol-2-yl)-2-methyl-2H-indazol-4-amine monohydrochloride | HCID 121924 | — |
Reaktionsschritte
4 g 4-amino-2-methyl-indazole is dissolved in 120 ml THF. The solution is treated with a solution of 2-chloro-imidazoline base, which is prepared from 10 g 2-chloro-imidazoline sulfate (prepared according to J. Heteroc. Chem. 11, 258) with 2n NaOH in methylene chloride.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04526898 |
| Quelldatensatz | uspto-grants-1985_07 |
| ORD ID | ord-c2ac97cefc304081a01a642abb6553d2 |
| Quellennotiz | uspto-grants-1985_07 |