Potassium Carbonate → Methyl (4-allylthio-3-ethylazetidin-2-on-1-yl)acetate

HRID 370508Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 370508
[CH2:1]([S:4][CH:5]1[NH:8][C:7](=[O:9])[CH:6]1[CH2:10][CH3:11])[CH:2]=[CH2:3].Br[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:17][O:16][C:14](=[O:15])[CH2:13][N:8]1[CH:5]([S:4][CH2:1][CH:2]=[CH2:3])[CH:6]([CH2:10][CH3:11])[C:7]1=[O:9]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 131064924-Allylthio-3-ethylazetidinone

Produkt 1

HCID 13106494Methyl (4-allylthio-3-ethylazetidin-2-on-1-yl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 2.34 g of 4-allylthio-3-ethylazetidinone in 20 ml of redistilled dimethylformamide were added 1.37 ml of methyl bromoacetate and 4.16 g of ground potassium carbonate. The solution was stirred overnight then filtered through a pad of Hyflo, (Hyflo being a Trade Mark), poured into 75 ml of water, and extracted five times with ethyl acetate. The combined organic extracts were washed with water, dried over magnesium sulphate, and evaporated in vacuo to give the title compound. (Yield 3 g)

Aufarbeitung

  1. filtrationthen filtered through a pad of Hyflo
  2. additionpoured into 75 ml of water
  3. extractionextracted five times with ethyl acetate
  4. washThe combined organic extracts were washed with water
  5. dry with materialdried over magnesium sulphate
  6. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2d84188b4a56427bb449539e0dfcdc04
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04526718

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