Potassium Carbonate → 2-(4-Methyl-1-piperidinyl)-5-nitro-4'-chlorobenzophenone

HRID 370727

Reaktionsgleichung

Reaktionsgleichung von HRID 370727
Cl[C:2]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[CH3:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C([O-])([O-])=O.[K+].[K+]>C(O)C>[CH3:20][CH:21]1[CH2:26][CH2:25][N:24]([C:2]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=2[C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=2)=[O:5])[CH2:23][CH2:22]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 693814-MethylpiperidineHCID 875720(2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanone

Produkt 1

HCID 131055022-(4-Methyl-1-piperidinyl)-5-nitro-4'-chlorobenzophenoneAusbeute 71,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 0.07 mole (20.7 g) of 2,4'-dichloro-5-nitrobenzophenone, of 0.1 mole (11.4 ml) of 4-methyl-piperidine and of 10 g of K2CO3 in 100 ml of anhydrous ethanol is heated to reflux for 3 hours. After cooling of the reaction medium, the precipitate obtained is filtered, washed with water, dried then recrystallized from ethanol. 18 g (yield=71.7%) of the expected product are thus obtained. M.p.=136° C.

Aufarbeitung

  1. temperatureto reflux for 3 hours
  2. temperatureAfter cooling of the reaction medium
  3. customthe precipitate obtained
  4. filtrationis filtered
  5. washwashed with water
  6. customdried
  7. customthen recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-02d7334024ea4d22a3a2a4fee15e4adf
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04528294

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