Methylamine → 5-(Methylamino)pyridine-3-carboxylic acid
Reaktionsgleichung
[CH3:1][NH2:2].Br[C:4]1[CH:5]=[N:6][CH:7]=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10]>C(O)C.O>[CH3:1][NH:2][C:4]1[CH:5]=[N:6][CH:7]=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The intermediate methyl 5-methylamino-nicotinate has been obtained as follows: reaction of methylamine (40% in water) with 5-bromo-nicotinic acid in autoclave at 140° C. for seven hours gives 5-methylamino-nicotinic acid, m.p. 239°-242° C. from ethanol/water; this acid reacts with SOCl in methanol under reflux for seven hours to afford the ester (methyl 5-methylaminonicotinate; m.p. 113°-115° C., from petroleum ether.
Quellen und Nachweise
- ORD-Eintrag
- ord-acda068c83224b3d9a07b870b2b38800
- Quelldatensatz
- uspto-grants-1985_07
- Patentnummer
- US04528296
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