Hydrochloric Acid → (2-Hydroxy-4-methoxyphenyl)(4-piperidinyl)methanone hydrochloride
Reaktionsgleichung
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:20])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[OH:19])[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[OH:19][C:12]1[CH:13]=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:11]=1[C:10]([CH:7]1[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]1)=[O:20]Komponenten
3
Versuchsvorschrift
To a round-bottom flask, equipped with a condenser and mechanical stirrer, was added 25.0 g of 1-acetyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine and 148 ml of 6N hydrochloric acid. The reaction mixture was stirred under reflux for 6 hrs and overnight at ambient temperature. The precipitate was collected, washed with acetone and recrystallized twice from ethanol to yield 16.70 g of product, mp, 264°-266°.
Aufarbeitung
- customTo a round-bottom flask, equipped with a condenser and mechanical stirrer
- customThe precipitate was collected
- washwashed with acetone
- custom