Methanol → Methyl 3-Hydroxyphenylacetate
Reaktionsgleichung
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH3:17]O>>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:17])=[O:10])[CH:5]=[CH:6][CH:7]=1Komponenten
4
Versuchsvorschrift
To a solution of 3-hydroxyphenylacetic acid (2 g, 13.2 mmol) in methanol (45 mL) was added concentrated H2SO4 (0.82 mL) and the mixture was heated at reflux for 18 h. Next, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and the solvent was removed, to yield 1.54 g of the desired compound (yield: 71%).
Aufarbeitung
- temperaturethe mixture was heated
- temperatureat reflux for 18 h
- customNext, the solvent was removed
- additionthe residue was diluted with water
- extractionextracted with ethyl acetate
- dry with materialThe organic phase was dried over anhydrous sodium sulfate
- customthe solvent was removed
Quellen und Nachweise
- ORD-Eintrag
- ord-bf58182e499b4b8590ee23072ae2a58a
- Quelldatensatz
- uspto-grants-1995_05
- Patentnummer
- US05420131
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