Methanol → Methyl 3-Hydroxyphenylacetate

HRID 37129

Reaktionsgleichung

Reaktionsgleichung von HRID 37129
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH3:17]O>>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:17])=[O:10])[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 121223'-Hydroxyphenylacetic acid

Produkt 1

HCID 39129Methyl 3-HydroxyphenylacetateAusbeute 71 %

Versuchsvorschrift

To a solution of 3-hydroxyphenylacetic acid (2 g, 13.2 mmol) in methanol (45 mL) was added concentrated H2SO4 (0.82 mL) and the mixture was heated at reflux for 18 h. Next, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and the solvent was removed, to yield 1.54 g of the desired compound (yield: 71%).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 h
  3. customNext, the solvent was removed
  4. additionthe residue was diluted with water
  5. extractionextracted with ethyl acetate
  6. dry with materialThe organic phase was dried over anhydrous sodium sulfate
  7. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-bf58182e499b4b8590ee23072ae2a58a
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05420131

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