Cyclohexylamine → HCID 18756975, Verbindung

HRID 371699

Reaktionsgleichung

Reaktionsgleichung von HRID 371699
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:8]([CH2:11][P:12](=[O:17])([O:15]C)[O:13]C)(O)=[O:9].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH:1]1([NH:7][C:8]([CH2:11][P:12](=[O:13])([OH:17])[OH:15])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 7965CyclohexylamineHCID 10868DicyclohexylcarbodiimideHCID 1899642-(Dimethoxyphosphoryl)acetic acid

Produkt 1

HCID 18756975HCID 18756975, VerbindungAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Cyclohexyl amine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide (0.045 mole) was added portionwise. The solution was stirred overnight and the mixture filtered. The filtrate was concentrated to a solid and the solid recrystallized from an appropriate solvent such as methanol. m.p. 180°-3° C.; yield 57%.

Aufarbeitung

  1. stirringThe solution was stirred overnight
  2. filtrationthe mixture filtered
  3. concentrationThe filtrate was concentrated to a solid
  4. customthe solid recrystallized from an appropriate solvent such as methanol

Quellen und Nachweise

ORD-Eintrag
ord-fa57d76245684623a517de4b633bf7ab
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04087522

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