19-Hydroxytestosterone → 1beta-Methyl-4-androstene-3alpha,17beta,19-triol

HRID 371834

Reaktionsgleichung

Reaktionsgleichung von HRID 371834
C(O)(=O)C.C(O)(=O)C.[OH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]2[C@H:16]3[C@H:27]([CH2:28][CH2:29][C@:11]12[CH3:12])[C@:24]1([CH2:25][OH:26])[C:19](=[CH:20][C:21](=[O:30])[CH2:22][CH2:23]1)[CH2:18][C@H:17]3[CH3:31].OC[C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)C(=O)CC4)CCC1=CC(=O)C[C@H]2C.O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@]1(CO)C(=CC(=O)CC1)CC3>>[CH3:18][C@H:19]1[C@@:24]2([CH2:25][OH:26])[C:23]([CH2:31][CH2:17][C@@H:16]3[C@@H:27]2[CH2:28][CH2:29][C@@:11]2([CH3:12])[C@H:13]3[CH2:14][CH2:15][C@@H:10]2[OH:9])=[CH:22][C@H:21]([OH:30])[CH2:20]1

Komponenten

4

Edukt 3

HCID 15096819-HydroxytestosteroneHCID 5427936919-Hydroxy-1beta-methyl-4-androsten-3,17-dioneHCID 8673568917beta,19-Dihydroxy-7alpha-methyl-4-androsten-3-one diacetate

Produkt 1

HCID 705851061beta-Methyl-4-androstene-3alpha,17beta,19-triol

Versuchsvorschrift

Following essentially the same procedure and substituting 17β,19-dihydroxy-7α-methyl-4-androsten-3-one diacetate, 7α-methyl-17β,19-di-(2'-tetrahydropyranyloxy)-4-androsten-3-one and 19-hydroxy-1β-methyl-4-androsten-3,17-dione for the 17β,19-dihydroxy-4-androsten-3-one above results in the preparation of 7α-methyl-4-androstene-3α,17β,19-triol 17β,19-diacetate, 7α-methyl-17β,19-di-(2'-tetrahydropyranyloxy)-4-androsten-3α-ol and 1β-methyl-4-androstene-3α,17β,19-triol, respectively.

Quellen und Nachweise

ORD-Eintrag
ord-b5685285bf2e498ea63e2e8449911c77
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04087524

Verknüpfte Notizen

Wird geladen…