HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminopyridine → 2-Methylimidazo[1,2-a]pyridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminopyridine | HCID 10439 | — |
| Edukt | Bromoacetone | HCID 11715 | — |
| Edukt | 1,1-Dimethylethyl 4'-[(2-butyl 4,5,6,7-tetrahydro pyrazolo(1,5-a)pyridin-3-yl)methyl](1,1'-biphenyl)2-carboxylate | HCID 19032469 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | 2-Methylimidazo[1,2-a]pyridine | HCID 136742 | 245,9% |
Reaktionsschritte
A mixture of 5 g of 2-amino pyridine and 250 ml of acetone were added at ambient temperature to a mixture of 7.25 g of 1 bromo 2-propanone and 20 ml of acetone and the mixture was refluxed for 30 minutes. Using the procedure of Stage C of Example 22, 5.3 g of the expected product were obtained in the form of an orange oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05420138 |
| Quelldatensatz | uspto-grants-1995_05 |
| ORD ID | ord-a3c2d8350f0a4600b896fc04423ca462 |
| Quellennotiz | uspto-grants-1995_05 |