2-Amino-3-methylpyridine → alpha-(Ethoxycarbonyl-methyl)-beta-(3-methyl-2-pyridyl-amino)-acrylic acid ethyl ester

Beteiligte Stoffe

Reaktionsschritte

10.8 g. (0.1 mole) of 3-methyl-2-amino-pyridine are admixed with 20.2 g. (0.1 mole) of 2-formyl-succinic acid diethyl ester. The reaction mixture warms up to 40°-50° C. The mixture is stirred for an hour, whereupon it is allowed to stand at room temperature overnight. The α-(ethoxycarbonyl-methyl)-β-(3-methyl-2-pyridyl-amino)-acrylic acid ethyl ester thus obtained is recrystallized from 50% aqueous ethanol. Yield: 65-70%, m.p.: 62° C.

Herkunft & Nachweise