Dicyclohexylcarbodiimide → HCID 20344450, Verbindung
Reaktionsgleichung
C1(N=C=NC2CCCCC2)CCCCC1.[C:16]([S:19][CH2:20][CH:21]([CH2:25][C:26](=O)[NH2:27])[C:22]([OH:24])=[O:23])(=[O:18])[CH3:17]>N1C=CC=CC=1>[C:16]([S:19][CH2:20][CH:21]([CH2:25][C:26]#[N:27])[C:22]([OH:24])=[O:23])(=[O:18])[CH3:17]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Dicyclohexylcarbodiimide (1.03 g.) is added to a solution of 3-acetylthio-2-carbamoylmethylpropanoic acid (1.02 g.) in pyridine (18 ml.). After 5 hours stirring at room temperature, the precipitate is filtered off and the filtrate is concentrated to dryness, the residue is dissolved in ethyl acetate and extracted with saturated aqueous bicarbonate. The aqueous phase is acidified and extracted with ethyl acetate. This organic layer is dried and concentrated to dryness. The residue, 3-acetylthio-2-cyanomethylpropanoic acid is crystallized from ether-hexane, m.p. 110°-112°.