4-Chloro-8-(trifluoromethyl)quinoline → dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate

HRID 372453

Reaktionsgleichung

Reaktionsgleichung von HRID 372453
[C:1]([O:10][CH2:11][P:12]([CH3:15])([CH3:14])=[O:13])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].Cl[C:17]1[C:26]2[C:21](=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:24][CH:25]=2)[N:20]=[CH:19][CH:18]=1>C(O)(C)C.Cl>[F:30][C:27]([F:28])([F:29])[C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:21]=1[N:20]=[CH:19][CH:18]=[C:17]2[NH:4][C:3]1[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:1]([O:10][CH2:11][P:12]([CH3:15])([CH3:14])=[O:13])=[O:9]

Komponenten

5

Edukt 2

HCID 902624-Chloro-8-(trifluoromethyl)quinolineHCID 12669155Dimethylphosphinylmethyl anthranilate

Produkt 1

HCID 12669152dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

4.6 grams (0.02 mol) of dimethylphosphinylmethyl anthranilate and 4.6 grams (0.02 mol) of 4-chloro-8-trifluoromethylquinoline are kept at 80° C for about 31/2 hours in 15 ml of isopropanol and 2.3 ml of concentrated aqueous hydrochloric acid. After removing the solvents and excess hydrochloric acid, the free base of the ester is liberated at 0° C. The dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate obtained is identical to that prepared in Example (2a). Yield 7.6 grams (90% of theory).

Aufarbeitung

  1. customare kept at 80° C for about 31
  2. customAfter removing the solvents and excess hydrochloric acid
  3. customis liberated at 0° C

Quellen und Nachweise

ORD-Eintrag
ord-73834c741bfc439da9a72fcec4cc69fd
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04091095

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