Phosphorus oxychloride → 3-(p-Bromophenyl)-6-chloro-4-methylpyridazine

HRID 372707Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 372707
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([CH3:15])=[CH:10][C:11](=O)[NH:12][N:13]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:18])=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([Cl:18])=[CH:10][C:9]=2[CH3:15])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychloride2×HCID 233336686-(p-bromophenyl)-5-methyl-3(2H)-pyridazinone

Produkt 1

HCID 203982893-(p-Bromophenyl)-6-chloro-4-methylpyridazine

Versuchsvorschrift

A 2.0 g. portion of 6-(p-bromophenyl)-5-methyl-3(2H)-pyridazinone and 20 ml. of phosphorus oxychloride are heated on a steam bath for 3 hours. The reaction mixture is poured slowly into crushed ice. The excess phosphorus oxychloride is decomposed. The solid which forms is recovered by filtration, washed with water, dried and recrystallized twice from chloroform, yielding 6-(p-bromophenyl)-5-methyl-3-chloropyridazine, m.p. 197°-200° C.

Aufarbeitung

  1. additionThe reaction mixture is poured slowly
  2. custominto crushed ice
  3. filtrationThe solid which forms is recovered by filtration
  4. washwashed with water
  5. customdried
  6. customrecrystallized twice from chloroform

Quellen und Nachweise

ORD-Eintrag
ord-7e7c0c4026c44048b47fb1c593e43e72
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04092311

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