HCID 11673142, Verbindung → HCID 53790063, Verbindung

HRID 372773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 372773
ClC1C=C(Cl)C(Cl)=CC=1O[C:11](=[O:31])[C@H:12]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].[CH2:32]([O:39][C:40](=[O:47])[C@H:41]([CH2:43][CH2:44][S:45][CH3:46])[NH2:42])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>C(Cl)Cl>[CH2:32]([O:39][C:40](=[O:47])[C@H:41]([CH2:43][CH2:44][S:45][CH3:46])[NH:42][C:11](=[O:31])[C@H:12]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[NH:13][C:14]([O:16][C:17]([CH3:18])([CH3:20])[CH3:19])=[O:15])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Komponenten

4

Edukt 2

HCID 11673142HCID 11673142, VerbindungHCID 22788750N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester

Produkt 1

HCID 53790063HCID 53790063, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 26.6 parts N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester and 12.0 parts L-methionine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. The solvent is then removed by evaporation under reduced pressure. The crude dipeptide is then subjected to low-pressure column chromatography on silica gel to afford N-t-butoxycarbonyl-L-tryptophyl-L-methionine benzyl ester.

Aufarbeitung

  1. customThe solvent is then removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a64ffbc761fa40b7bf66da369a1f19f6
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04092304

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