Benzyl L-leucinate → N-t-butoxycarbonylglycyl-L-leucine benzyl ester

HRID 372783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 372783
ClC1C=C(Cl)C(Cl)=CC=1[O:10][C:11](=O)[CH2:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].[CH2:22]([O:29][C:30](=[O:37])[C@H:31]([CH2:33][CH:34]([CH3:36])[CH3:35])[NH2:32])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(Cl)Cl>[CH2:22]([O:29][C:30](=[O:37])[C@H:31]([CH2:33][CH:34]([CH3:35])[CH3:36])[NH:32][C:11](=[O:10])[CH2:12][NH:13][C:14]([O:16][C:17]([CH3:19])([CH3:18])[CH3:20])=[O:15])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Komponenten

4

Edukt 2

HCID 6451313Benzyl L-leucinateHCID 12799284t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl Ester

Produkt 1

HCID 53703413N-t-butoxycarbonylglycyl-L-leucine benzyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 19.5 parts N-t-butoxycarbonylglycine 2,4,5-trichlorophenyl ester and 11.1 parts L-leucine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. The solvent is then removed by evaporation under reduced pressure. The crude dipeptide is then subjected to low-pressure column chromatography on silica gel to afford N-t-butoxycarbonylglycyl-L-leucine benzyl ester.

Aufarbeitung

  1. customThe solvent is then removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0ac71ffc126449cab9a5591baaaff651
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04092304

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