Benzyl Chloride → N,N-Dimethyl-N-(2-benzoylaminoethyl)benzylammonium Chloride

HRID 372939

Reaktionsgleichung

Reaktionsgleichung von HRID 372939
[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[Cl:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(#N)C>[Cl-:15].[CH3:1][N+:2]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:14])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 7503Benzyl ChlorideHCID 113158N-(2-(Dimethylamino)ethyl)benzamide

Produkt 1

HCID 19811098N,N-Dimethyl-N-(2-benzoylaminoethyl)benzylammonium Chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 19.23 grams (0.10 mol) of the N-(2-dimethylaminoethyl)benzamide, prepared as described in Example 1, 12.66 grams (0.10 mol) of α-chlorotoluene and 64 milliters of acetonitrile was heated at reflux for 19.75 hours. Solid crystallized on cooling which was collected, washed with acetonitrile and dried. The yield of product was 24.0 grams (75.27% of theory); mp=175°-176° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 19.75 hours
  3. customSolid crystallized
  4. temperatureon cooling which
  5. customwas collected
  6. washwashed with acetonitrile
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-80630acfb6e64d19be126317e4c1d130
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05162188

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