Pyrazole → 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole

HRID 373006

Reaktionsgleichung

Reaktionsgleichung von HRID 373006
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16]Br)[CH2:9][CH2:8]1.[NH:18]1[CH:22]=[CH:21][CH:20]=[N:19]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)[CH2:9][CH2:8]1

Komponenten

5

Edukt 3

HCID 1048PyrazoleHCID 11430Potassium CarbonateHCID 147268432-(4-(4-Bromobutyl)piperazin-1-yl)pyrimidine

Produkt 1

HCID 110443661-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 4 g (13.3 mmol) of 1-(2-pyrimidinyl)-4-(4-bromobutyl)piperazine, 1.02 g (15 mmol) of pyrazole and 2.76 g (20 mmol) of potassium carbonate in 50 ml of dimethylformamide is heated to reflux for 14 hours. The mixture is evaporated under vacuum, chloroform is added, the organic phase is washed with water, dried over sodium sulphate and evaporated under vacuum, and 3.5 g of an oil which is 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1H-pyrazole are obtained.

Aufarbeitung

  1. temperatureis heated
  2. temperatureto reflux for 14 hours
  3. customThe mixture is evaporated under vacuum, chloroform
  4. additionis added
  5. washthe organic phase is washed with water
  6. dry with materialdried over sodium sulphate
  7. customevaporated under vacuum, and 3.5 g of an oil which
  8. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-88d5f208d48e4fefa8dfa751ff185f9e
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05162323

Verknüpfte Notizen

Wird geladen…